To configure vSphere vMotion networking, what must you set up?

To configure vSphere vMotion networking, it is essential to set up a VMkernel adapter specifically designed for vMotion. This VMkernel adapter is a virtual network interface that enables the communication required for the migration of virtual machines (VMs) from one host to another without any downtime. Activating the vSphere vMotion service on this adapter allows the network traffic necessary for vMotion operations to flow between the hosts involved in the migration process.

While the other options may play roles in the broader context of vSphere networking or storage configurations, they are not specifically required for enabling vSphere vMotion. A datastore cluster, for instance, relates more to the storage resources managed by vSphere rather than the networking specifics of VMotion. Standard switch configuration and distributed switch settings serve different networking needs and do not directly pertain to establishing the vMotion service on the VMkernel adapter. Thus, option B is critical as it directly addresses the necessity of having a configured VMkernel adapter with vMotion capabilities for successful VM migrations.