Can you migrate a VM from a host with an IPv4 address to a host with an IPv6 address using vSphere vMotion?

The correct answer is that you cannot migrate a virtual machine (VM) from a host with an IPv4 address to a host with an IPv6 address using vSphere vMotion. This limitation is due to the fundamental differences in network protocols. vSphere vMotion requires that the source and destination hosts have compatible networking configurations. Since IPv4 and IPv6 are distinct protocols, seamless migration between hosts employing different addressing schemes is not feasible.

For vMotion to succeed, both the source and destination hosts must exist in the same vSphere network environment and be configured to communicate using the same IP addressing scheme. This ensures that data packets can be transferred without any network layer compatibility issues. Additionally, the migration process relies on the underlying network infrastructure to be uniform across the participating hosts, which would not be possible if one host is using IPv4 and the other IPv6.

While some options imply conditions under which such a migration could occur, those scenarios do not alter the core issue related to network protocol compatibility that makes this migration impossible in practice.